Granular cell tumors of the urethra.

Konstantinos Evmorfopoulos, Vassilios Tzortzis, Panagiotis J Vlachostergios

Cancer treatment and research communications 2023

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Granular cell tumors (GCTs) are a rare type of mesenchymal tumors that are histologically derived by Schwann cells and rise within soft tissues such as skin and mucosal surfaces. Differentiation between benign and malignant GCTs is often difficult and relies on their biological behavior and metastatic potential. While there are no standard guidelines for management, upfront surgical resection, whenever feasible, is key as a definitive measure. Systemic therapy is often limited by poor chemosensitivity of these tumors; however, accumulating knowledge of their underlying genomic landscape has opened some opportunities for targeted approaches, for example, the vascular endothelial growth factor tyrosine kinase inhibitor pazopanib, which is already in clinical use for the treatment of many types of advanced soft tissue sarcomas. Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Citation

Konstantinos Evmorfopoulos, Vassilios Tzortzis, Panagiotis J Vlachostergios. Granular cell tumors of the urethra. Cancer treatment and research communications. 2023;35:100695