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The current synthesis routes of anthocyanins are relatively complicated, which significantly hinders their development. We optimized the method by introducing a selective iodination reaction and also established a general scheme for preparing anthocyanin diglycosides. This method allows anthocyanin synthesis to require fewer steps and costs. Based on this, we prepared four common anthocyanins and two anthocyanin diglucosides and measured their antioxidant and anti-insulin resistance activities.


Jun Hu, Yue Li, Guangkai Wu, Shuer Liang, Zihan Zhao, Jia Liu, Jiali Chen, Guocan Yu, Jianxia Sun, Weibin Bai. Selective Iodination Enables Anthocyanin Synthesis to Be More General. Organic letters. 2023 Apr 07;25(13):2289-2293

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PMID: 36946509

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