Lutein-stachyose (LS) amphiphilic oligosaccharide derivatives improve the oral bioavailability of lutein.

Yuanyuan Li, Bingxue Liu, Xiaoxue Zhang, Yanjie Liu, Siying Wang, Shujun Li, Xiuhua Zhao

Food chemistry 2023 Aug 30

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A new amphiphilic oligosaccharide derivative, based on lutein modification onto the OH position of stachyose with facile and mild esterification, was prepared and used to improve the oral bioavailability of lutein. The structures of lutein-stachyose derivative (LS) were confirmed by Fourier transform infrared spectroscopy and hydrogen-1 nuclear magnetic resonance, indicating that one stachyose is connected to one lutein through succinic acid. The critical micelle concentration of LS was approximately 6.86 ± 0.24 mg/mL, corresponding to the free lutein concentration of approximately 2.96 mg/mL. LS has better digestive stability and free radical scavenging ability, and it could inhibit the degradation of lutein in the gastrointestinal tract. Importantly, LS is nontoxic to cells and zebrafish embryos. In terms of oral bioavailability in rats, the AUC0-12h values of LS were 2.26 times higher than those of free lutein. Therefore, stachyose modification is a promising strategy for improving the oral bioavailability of fat-soluble lutein. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Yuanyuan Li, Bingxue Liu, Xiaoxue Zhang, Yanjie Liu, Siying Wang, Shujun Li, Xiuhua Zhao. Lutein-stachyose (LS) amphiphilic oligosaccharide derivatives improve the oral bioavailability of lutein. Food chemistry. 2023 Aug 30;418:136032