Effects of a high-fat diet on rat epididymis.

The epididymis plays an essential role in reproduction, promoting sperm cell maturation. In this study, we investigated the effects of a high-fat diet (HFD) in the three regions of the epididymis of rats, including caput, corpus, and cauda. Our results showed an increase in malondialdehyde and a decrease in superoxide dismutase, which indicated an increase in oxidative stress in all segments of the epididymis. The cellular response mechanisms were mostly detected in the corpus/cauda regions, which showed an increase in apoptosis, probably for eliminating dysfunctional cells arising from HFD-induced oxidative stress, and a decrease in mitophagy. Additionally, an increase in lipophagy to prevent lipid accumulation and a decrease in cell proliferation were recorded in the corpus. © 2023 The Authors. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology published by Wiley Periodicals LLC.

Citation

Sara Falvo, Debora Latino, Alessandra Santillo, Gabriella Chieffi Baccari, Rosalba Senese, Francesca Nuzzolillo, Maria Maddalena Di Fiore. Effects of a high-fat diet on rat epididymis. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2023 Jul;339(6):535-544

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PMID: 37009779

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