Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity.

Wataru Kadowaki, Ryo Miyata, Sayaka Mizuno, Misa Fujinami, Yoshizumi Sato, Shigenori Kumazawa

Bioscience, biotechnology, and biochemistry 2023 Jun 23

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Calendula officinalis is a medicinal plant in the Asteraceae family, and it has a broad range of biological activities. In this study, we focused on the roots of C. officinalis, which have remarkable anti-inflammatory properties. By using a bioassay-guided fractionation approach, prenylated acetophenones 1 and 2-of which 1 was previously unknown-were isolated, and their structures were determined by spectroscopic analysis. Both compounds decreased lipopolysaccharide-stimulated NO production in J774.1 cells. This study could lead to the use of the Calendula roots as a natural source of inflammatory mediators. © The Author(s) 2023. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.

Citation

Wataru Kadowaki, Ryo Miyata, Sayaka Mizuno, Misa Fujinami, Yoshizumi Sato, Shigenori Kumazawa. Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity. Bioscience, biotechnology, and biochemistry. 2023 Jun 23;87(7):683-687