The tanshinones from the plant of Salvia miltiorrhiza.

Jian-Shuang Jiang, Quan-Chang Gu, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang, Ya-Nan Yang

Phytochemistry 2023 Jun

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Six undescribed tanshinones, (+)-2-Cl-tanshindiol C (1), (-)-2-Cl-tanshindiol C (2), (+)-tanshinoic acid D (3), (-)-tanshinoic acid D (4), (-)-tanshinoic acid E (5), and (+)-tanshinoic acid E (6), were isolated from the rhizome of Salvia miltiorrhiza Bunge. Their structures were elucidated based on the spectroscopic data (UV, IR, HR-ESI-MS, and NMR). The bioactive assays of all these compounds for the antioxidant activities in cardiomyocytes upon hypoxia stimulation were evaluated. The results suggested that compounds 5 and 6 exhibited good antioxidant activities in cardiomyocytes and the cell survival rates were 46.3% and 57.9% (10-5 mol/L), respectively. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Jian-Shuang Jiang, Quan-Chang Gu, Zi-Ming Feng, Xiang Yuan, Xu Zhang, Pei-Cheng Zhang, Ya-Nan Yang. The tanshinones from the plant of Salvia miltiorrhiza. Phytochemistry. 2023 Jun;210:113673