Factor VII deficiency: A cause of (or risk factor for) bleeding?

Daniel J Hampshire

British journal of haematology 2023 Aug

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Among the rare bleeding disorders factor VII deficiency is the most common, but correlating deficiency with bleeding phenotype is challenging. In their study Lou and colleagues investigate a large cohort of unrelated factor VII deficient patients providing a further perspective on the link between genotype and phenotype in this disorder. Commentary on: Lou et al. Structural and functional characterization of novel F7 mutations identified in Chinese factor VII deficient patients. Br J Haematol. 2023;202:623-635. © 2023 British Society for Haematology and John Wiley & Sons Ltd.