Local ocular safety of the subconjunctival injection of cetuximab in rabbits.

Hossein Aghaei, Ahmad Kheirkhah, Ali Mohammad Alizadeh, Acieh Es'haghi, Roshanak Aliakbar-Navahi, Zahra Keikha, Samira Chaibakhsh

BMC ophthalmology 2023 Apr 13

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To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe. © 2023. The Author(s).

Citation

Hossein Aghaei, Ahmad Kheirkhah, Ali Mohammad Alizadeh, Acieh Es'haghi, Roshanak Aliakbar-Navahi, Zahra Keikha, Samira Chaibakhsh. Local ocular safety of the subconjunctival injection of cetuximab in rabbits. BMC ophthalmology. 2023 Apr 13;23(1):155