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A 61-year-old man presented with dyschezia, and further examination revealed squamous cell carcinoma of the lower rectum invading the bladder and seminal vesicles. The clinical diagnosis was squamous cell carcinoma of the lower rectum, cT4b(bladder and seminal vesicle)N0M0, cStage Ⅱc. Neoadjuvant chemoradiotherapy was administered with external irradiation of the entire pelvis(50.4 Gy/28 Fr)and chemotherapy with 5-fluorouracil, Leucovorin, and oxaliplatin(FOLFOX). Once tumor shrinkage was observed 3 months after chemoradiotherapy, laparoscopic total pelvic exenteration with TaTME approach was performed. The patient was discharged on the 26th postoperative day without any postoperative complications. Histopathological examination showed only squamous cell carcinoma component with Grade 1a histological treatment effect. The pathological diagnosis was ypT4b(bladder, seminal vesicle)ypN0cM0, ypStage Ⅱc. The patient was alive without any recurrence 6 months after surgery.


Mao Osaki, Tsuyoshi Hata, Yuki Sekido, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Daisuke Sakai, Mamoru Uemura, Taroh Satoh, Yuichiro Doki, Hidetoshi Eguchi. A Case of Squamous Cell Carcinoma of the Lower Rectum]. Gan to kagaku ryoho. Cancer & chemotherapy. 2023 Apr;50(4):508-510

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PMID: 37066470

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