Mehmet Refik Bahar, Suat Tekin, Asiye Beytur, Ebru Etem Onalan, Fatma Ozyalin, Cemil Colak, Süleyman Sandal
Biologia futura 2023 JunThis study was conducted to determine the possible effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins (UCPs) in rats. Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 µM MOTS-c. Hypothalamus, blood, muscle, adipose tissues samples were collected for thyrotropin-releasing hormone (TRH), UCP1 and UCP3 levels were determined by the RT-PCR and western blot analysis. Serum thyroid hormone levels were determined by the ELISA assays. MOTS-c infusion was found to increase food consumption but it did not cause any changes in the body weight. MOTS-c decreased serum TSH, T3, and T4 hormone levels. On the other hand, it was also found that MOTS-c administration increased UCP1 and UCP3 levels in peripheral tissues. The findings obtained in the study show that central MOTS-c infusion is a directly effective agent in energy metabolism. © 2023. Akadémiai Kiadó Zrt.
Mehmet Refik Bahar, Suat Tekin, Asiye Beytur, Ebru Etem Onalan, Fatma Ozyalin, Cemil Colak, Süleyman Sandal. Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins. Biologia futura. 2023 Jun;74(1-2):159-170
PMID: 37067760
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