Dynamic Hydrogen-Bonded Zinc Adeninate Framework (ZAF) for Immobilization of Catalytic DNA.

Walaa S Baslyman, Othman Alahmed, Santanu Chand, Somayah Qutub, Niveen M Khashab

Angewandte Chemie (International ed. in English) 2023 Jun 19

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Effective immobilization and delivery of genetic materials is at the forefront of biological and medical research directed toward tackling scientific challenges such as gene therapy and cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting of zinc adeninate macrocycles that self-assemble into a 3D framework through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation and physiological conditions until it is successfully delivered into the nucleus. As compared to zeolitic imidazolate frameworks (ZIFs), ZAFs are twofold more biocompatible with a significant loading efficiency of 96 %. Overall, our design paves the way for expanding functional hydrogen-bonding-based systems as potential platforms for the loading and delivery of biologics. © 2023 Wiley-VCH GmbH.

Citation

Walaa S Baslyman, Othman Alahmed, Santanu Chand, Somayah Qutub, Niveen M Khashab. Dynamic Hydrogen-Bonded Zinc Adeninate Framework (ZAF) for Immobilization of Catalytic DNA. Angewandte Chemie (International ed. in English). 2023 Jun 19;62(25):e202302840