Functional genomics and systems biology of Cordyceps species for biotechnological applications.

Nachon Raethong, Roypim Thananusak, Pattsarun Cheawchanlertfa, Pranesha Prabhakaran, Kittipong Rattanaporn, Kobkul Laoteng, Mattheos Koffas, Wanwipa Vongsangnak

Current opinion in biotechnology 2023 Jun

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The use of Cordyceps species for the manufacture of natural products has been established; however, the tremendous advances observed in recent years in genetic engineering and molecular biology have revolutionized the optimization of Cordyceps as cell factories and drastically expanded the biotechnological potential of these fungi. Here, we present a review of systems and synthetic biology studies of Cordyceps and their implications for fungal biology and industrial applications. We summarize the current status of synthetic biology for enhancing targeted metabolites in Cordyceps species, such as cordycepin, adenosine, polysaccharide, and pentostatin. Progress in the systems and synthetic biology of Cordyceps provides a strategy for comprehensively comprehensive controlling efficient cell factories of natural bioproducts and novel synthetic biology toolbox for targeted engineering. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Nachon Raethong, Roypim Thananusak, Pattsarun Cheawchanlertfa, Pranesha Prabhakaran, Kittipong Rattanaporn, Kobkul Laoteng, Mattheos Koffas, Wanwipa Vongsangnak. Functional genomics and systems biology of Cordyceps species for biotechnological applications. Current opinion in biotechnology. 2023 Jun;81:102939