Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Spinal cord injury (SCI) is a serious central nervous system disease. Traumatic SCI often causes persistent neurological deficits below the injury level. Epigenetic changes occur after SCI. Studies have shown DNA methylation to be a key player in nerve regeneration and remodeling, and in regulating some pathophysiological characteristics of SCI. Curcumin is a natural polyphenol from turmeric. It has anti-inflammatory, antioxidant, and neuroprotective effects, and can mitigate the cell and tissue damage caused by SCI. This report analyzed the specific functions of DNA methylation in central nervous system diseases, especially traumatic brain injury and SCI. DNA methylation can regulate the level of gene expressions in the central nervous system. Therefore, pharmacological interventions regulating DNA methylation may be promising for SCI. © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Yu Zhou, Yong Zhang, Benson O A Botchway, Xichen Wang, Xuehong Liu. Curcumin can improve spinal cord injury by inhibiting DNA methylation. Molecular and cellular biochemistry. 2024 Feb;479(2):351-362

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 37076656

View Full Text