Ecological and human health hazards; integrated risk assessment of organochlorine pesticides (OCPs) from the Chenab River, Pakistan.

Carcinogenic hazards to human health were investigated through oral and dermal exposure to organochlorine pesticides (OCPs) from water samples (n = 120) of River Chenab, Pakistan. The Pioneering study aimed to employ an integrated geographic information system (GIS) based geostatistical method for the determination of pollution load by GC-ECD from water of River Chenab. The residual levels of OCPs detected from water samples ranged from 0.54 to 122 ng L-1 with significant prevalence of DDE and α-HCH. Results of the Nemerrow pollution index (NeI), single pollution index (SPI), and comprehensive pollution index (CPI) reflected the downstream zone a stern pollution risk zone. The spatial distribution pattern through geostatistical approaches also revealed significantly higher (p < 0.05) OCP levels in the downstream zone. Risk quotient (RQCCC) of surface water quality with respect to heptachlor epitomized a high level of risk (RQCCC > 1). Non-carcinogenic human health risk (Σ HQ) assessment ranged from 8.39 × 10-9 to 1.7 × 10-3, which represented a marginal risk through oral and dermal exposure. However, carcinogenic risks by oral exposure route were ranged from 3.57 × 10-11 to 4.46 × 10-6. Estimated cancer risk (ΣCR) exhibited a considerable carcinogenic risk posed by heptachlor, α-HCH and dieldrin. It is suggested to employ an immediate mitigation strategy for the constant discharge of OCPs in the studied area. Copyright © 2023. Published by Elsevier B.V.

Citation

Sidra Siddique, M Nawaz Chaudhry, Sajid Rashid Ahmad, Rabia Nazir, Zhen Zhao, Rimsha Javed, Huda Ahmed Alghamdi, Adeel Mahmood. Ecological and human health hazards; integrated risk assessment of organochlorine pesticides (OCPs) from the Chenab River, Pakistan. The Science of the total environment. 2023 Jul 15;882:163504

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PMID: 37080307

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