Correlation Engine 2.0
Clear Search sequence regions

  • adipocytokines (1)
  • breeds (2)
  • genotypes (1)
  • insulin (1)
  • RETN (11)
  • sheep (8)
  • SNP (3)
  • weight (1)
  • Sizes of these terms reflect their relevance to your search.

    Resistin is one of the most important adipocytokines in mammalian cells due to its involvement in insulin resistance, obesity, and autoimmune diseases. Resistin is encoded by RETN gene that is primarily expressed in adipose tissues. Mutations in this gene have been associated with several productive traits in animals. This study was conducted to assess the possible biomarker capacity of RETN by evaluating its association with growth traits in two economically important sheep in the Middle East. Genotyping was conducted using PCR-single strand conformation polymorphism (SSCP), and the polymorphism of RETN was associated with several growth traits for three months intervals starting from birth until one year of age. In a total of 190 Karakul sheep and 245 Awassi sheep, only one SNP (233A > C) was detected in the RETN gene. The identified novel SNP showed significant associations with all growth traits at the ages of six, nine, and twelve months. At the age of six months onward, lambs with AC and CC genotypes showed respectively lower body weight and length, chest and abdominal circumferences, and wither and rump heights than those with AA genotype. Due to the remarkable association between RETN;233A > C and lower growth traits, this genotype is suggested as a promising marker to assess growth traits in Karakul and Awassi sheep. This is the first study that demonstrated the importance of RETN as a possible tool for evaluating growth traits in two breeds of sheep with a possibility to be applied to other breeds via large-scale association analysis. © 2023. The Author(s), under exclusive licence to Springer Nature B.V.


    Thamer R S Aljubouri, Mohammed Baqur S Al-Shuhaib. The identification of a novel SNP in the resistin (RETN) gene associated with growth traits in Karakul and Awassi sheep. Tropical animal health and production. 2023 Apr 21;55(3):165

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37084102

    View Full Text