Research progress on the immunomodulatory effects and mechanisms of trace amine-associated receptor 1].

Xian-Qiang Zhang, Ji-Tao Li, Tian-Mei Si, Yun-Ai Su

Sheng li xue bao : [Acta physiologica Sinica] 2023 Apr 25

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Trace amines are endogenous molecules distributed in the central nervous system and peripheral tissues that resemble common biogenic amines in terms of subcellular localization, chemical structure, and metabolism. Trace amine-associated receptor (TAAR) is a kind of evolutionarily conserved G-protein-coupled receptors in vertebrates, in which TAAR1 is a functional regulator of monoamine transmitters such as dopamine and serotonin. TAAR1 is widely considered as a potential therapeutic target for schizophrenia, depression and drug addiction. Moreover, TAAR1 is also expressed in peripheral tissues. The homeostasis imbalance of trace aminergic system can induce over-activation of peripheral immune system and central immune inflammatory response. TAAR1 modulators are becoming potential emerging drugs for the treatment of immune-related illnesses, because they may play a major role in the activation or modulation of immune response.

Citation

Xian-Qiang Zhang, Ji-Tao Li, Tian-Mei Si, Yun-Ai Su. Research progress on the immunomodulatory effects and mechanisms of trace amine-associated receptor 1]. Sheng li xue bao : [Acta physiologica Sinica]. 2023 Apr 25;75(2):248-254