Coronavirus genomic cDNA derived G-quadruplex as a selective target for fluorometric detection.

Sumon Pratihar, Mohamed Nabeel Mattath, Thimmaiah Govindaraju

Chemical communications (Cambridge, England) 2023 May 09

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Pathogenic genomes harboring noncanonical G-quadruplex (GQ) forming sequences are potential targets for diagnosis. The GQ-forming cDNA sequences of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus-2) are identified and validated as reliable diagnostic targets. The high fidelity fluorescence detection of specific cDNA GQs derived from the SARS-CoV-2 RNA genome is demonstrated using small molecular probes.

Citation

Sumon Pratihar, Mohamed Nabeel Mattath, Thimmaiah Govindaraju. Coronavirus genomic cDNA derived G-quadruplex as a selective target for fluorometric detection. Chemical communications (Cambridge, England). 2023 May 09;59(38):5717-5720