Demethyl oxidative halogenation of diacyl dimethylsulfonium methylides.

α-Halo-α-methylthio-β-ketosulfones containing a quaternary halocarbon stereocenter were prepared via selective demethyl oxidative halogenations of diacyl dimethylsulfonium methylides in moderate to excellent yields (39 examples; up to 98%). The current protocols directly and efficiently introduce a halogen atom into organic compounds with high functional group tolerance under metal-free conditions.

Citation

Duo Fu, Changmeng Xi, Jiaxi Xu. Demethyl oxidative halogenation of diacyl dimethylsulfonium methylides. Organic & biomolecular chemistry. 2023 May 17;21(19):3991-3996

PMID: 37114954

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