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    Co-occurrence of antipsychotic-induced weight gain (AIWG) and therapeutic response (TR) did exist in clinic but was rarely studied. This study aims to identify potential TR/ AIWG biotypes and explore the clinical, genetic and neuroimaging features. This study enrolled 3030 patients to identify potential TR/AIWG biotypes and explore the clinical, genetic and neuroimaging features. We found three biotypes: TR+nonAIWG (46.91%), TR+AIWG (18.82%), and nonTR+nonAIWG (34.27%). TR+AIWG showed lower weight and lipid level at baseline, but higher changing rate, and higher genetic risk of obesity than TR+nonAIWG and nonTR+nonAIWG. GWAS identified ADIPOQ gene related to TR+AIWG biotypes and top-ranked loci enriched in one-carbon metabolic process, which related to both schizophrenia and metabolic dysfunction. Genetically predicted TR+AIWG was associated with higher odds of diabetes (OR=1.05). The left supplementary motor area was significantly negatively correlated with PRS of obesity. The distinguishing ability with multi-omics data to identify TR+AIWG reached 0.787. In a word, the "thin" patients with a higher risk of obesity are the target population of early intervention. Copyright © 2023 Elsevier B.V. All rights reserved.


    Zhe Lu, Yuyanan Zhang, Yaoyao Sun, Yundan Liao, Zhewei Kang, Xiaoyang Feng, Hao Yan, Jun Li, Lifang Wang, Tianlan Lu, Dai Zhang, Yu Huang, Weihua Yue. The positive association between antipsychotic-induced weight gain and therapeutic response: New biotypes of schizophrenia. Psychiatry research. 2023 Jun;324:115226

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    PMID: 37116323

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