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    From the time of its discovery and isolation in the mammalian hypothalamus, the decapeptide, gonadotropin-releasing hormone (GnRH), has also been found to be expressed in non-hypothalamic tissues and can elicit a diverse array of functions both in the brain and periphery. In cancer, past studies have targeted the gonadotropin-releasing hormone receptors (GnRHR) as a way to treat reproductive cancers due to its anti-tumorigenic effects. On the contrary, its metabolite, GnRH-(1-5), behaves divergently from its parental peptide through putative orphan G-protein coupled receptor (oGPCR), GPR101. In this review, we will focus on the potential roles of GnRH-(1-5) in the periphery with an emphasis on its effects on endometrial cancer progression. Copyright © 2023 Cho-Clark, Watkins and Wu.


    Madelaine J Cho-Clark, Allison Watkins, T John Wu. The role of GnRH metabolite, GnRH-(1-5), in endometrial cancer. Frontiers in endocrinology. 2023;14:1183278

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    PMID: 37124730

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