Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging.

There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.

Citation

Gonzalo Soto-Heredero, Manuel M Gómez de Las Heras, J Ignacio Escrig-Larena, María Mittelbrunn. Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging. Annual review of immunology. 2023 Apr 26;41:181-205

Mesh Tags

PMID: 37126417

search → result