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DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221086) develop D1-/-, D1L3-/-, and D1-/-D1L3-/- mice to show that exogenous addition of the DNase formulation Dornase alfa can facilitate removal of biofilms. © 2023 Bhattacharya and Horswill.
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Mohini Bhattacharya, Alexander R Horswill. Breaking bad. The Journal of experimental medicine. 2023 Jun 05;220(6)
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PMID: 37129875
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