Exposure to polystyrene particles causes anxiety-, depression-like behavior and abnormal social behavior in mice.

In the era of plastic use, organisms are constantly exposed to polystyrene particles (PS-Ps). PS-Ps accumulated in living organisms exert negative effects on the body, although studies evaluating their effects on brain development are scarce. In this study, the effects of PS-Ps on nervous system development were investigated using cultured primary cortical neurons and mice exposed to PS-Ps at different stages of brain development. The gene expression associated with brain development was downregulated in embryonic brains following PS-Ps exposure, and Gabra2 expression decreased in the embryonic and adult mice exposed to PS-Ps. Additionally, offspring of PS-Ps-treated dams exhibited signs of anxiety- and depression-like behavior, and abnormal social behavior. We propose that PS-Ps accumulation in the brain disrupts brain development and behavior in mice. This study provides novel information regarding PS-Ps toxicity and its harmful effects on neural development and behavior in mammals. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Citation

Hyun Seung Shin, Seung Hyun Lee, Ha Jung Moon, Yun Hee So, Ha Ram Lee, Eun-Hee Lee, Eui-Man Jung. Exposure to polystyrene particles causes anxiety-, depression-like behavior and abnormal social behavior in mice. Journal of hazardous materials. 2023 Jul 15;454:131465

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PMID: 37130475

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