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Immune functions are influenced by the nutritional state. In a recent publication in Immunity, Janssen et al. unveil that a fasting-induced glucocorticoid release makes monocytes move from blood into the bone marrow. Upon refeeding, these chronologically older monocytes are again released and exert detrimental effects during bacterial infection. Copyright © 2023 Elsevier Inc. All rights reserved.


Jan Tuckermann, Pamela Fischer-Posovszky. Energy saver: Monocytes hibernate in bone marrow upon fasting. Cell metabolism. 2023 May 02;35(5):734-736

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PMID: 37137288

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