Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game.

In this article, I discuss recent work by Pankhurst et al. They found that MAIT cells can serve as a cellular adjuvant to boost immunity to a protein adjuvant. Intranasal co-administration of protein antigen with a strong MAIT cell ligand results in the the production of mucosal IgA and IgG antibody responses. This process is driven by MAIT cell-mediated maturation of migratory dendritic cells. © 2023 the Australian and New Zealand Society for Immunology, Inc.

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Nicholas M Provine. Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game. Immunology and cell biology. 2023 Jul;101(6):470-472

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PMID: 37137689

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