Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits.

Manzar Alam, Summya Rashid, Kisa Fatima, Mohd Adnan, Alaa Shafie, Mohammad Salman Akhtar, A H Ganie, Sayed M Eldin, Asimul Islam, Ilyas Khan, Md Imtaiyaz Hassan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul

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α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective, antimicrobial, antioxidant, and anti-inflammatory properties, and induces apoptosis. α-MG controls cell proliferation by modulating signaling molecules, thus implicated in cancer therapy. It possesses incredible pharmacological features and modulates crucial cellular and molecular factors. Due to its lesser water solubility and pitiable target selectivity, α-MG has limited clinical application. As a known antioxidant, α-MG has gained significant attention from the scientific community, increasing interest in extensive technical and biomedical applications. Nanoparticle-based drug delivery systems were designed to improve the pharmacological features and efficiency of α-MG. This review is focused on recent developments on the therapeutic potential of α-MG in managing cancer and neurological diseases, with a special focus on its mechanism of action. In addition, we highlighted biochemical and pharmacological features, metabolism, functions, anti-inflammatory, antioxidant effects and pre-clinical applications of α-MG. Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Manzar Alam, Summya Rashid, Kisa Fatima, Mohd Adnan, Alaa Shafie, Mohammad Salman Akhtar, A H Ganie, Sayed M Eldin, Asimul Islam, Ilyas Khan, Md Imtaiyaz Hassan. Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul;163:114710