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    There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training. Copyright © 2023 Elsevier Inc. All rights reserved.


    Wei Wei, Nicholas M Riley, Xuchao Lyu, Xiaotao Shen, Jing Guo, Steffen H Raun, Meng Zhao, Maria Dolores Moya-Garzon, Himanish Basu, Alan Sheng-Hwa Tung, Veronica L Li, Wentao Huang, Amanda L Wiggenhorn, Katrin J Svensson, Michael P Snyder, Carolyn R Bertozzi, Jonathan Z Long. Organism-wide, cell-type-specific secretome mapping of exercise training in mice. Cell metabolism. 2023 Jul 11;35(7):1261-1279.e11

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    PMID: 37141889

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