An Experimental Model of Chromoblastomycosis Caused by Fonsecaea sp. Species.

Anamelia L Bocca, Isaque Medeiros Siqueira

Methods in molecular biology (Clifton, N.J.) 2023

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The experimental rodent models for the fungal disease are a handy tool for understanding host-fungus interactions. To Fonsecaea sp., one of the causative agents of chromoblastomycosis, there is an extra challenge because the animals preferably used show a spontaneous cure; so until now, there is no model to reproduce the long-term disease similar to human chro nic disease. In this chapter, we described an experimental model using rats and mice with a subcutaneous route, with the checkpoints of acute-like and chronic-like lesion analysis comparable with human lesions, the fungal burden, and the lymphocytes investigation. © 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Anamelia L Bocca, Isaque Medeiros Siqueira. An Experimental Model of Chromoblastomycosis Caused by Fonsecaea sp. Species. Methods in molecular biology (Clifton, N.J.). 2023;2667:129-138