Mechanistic Role of Tempol: Synthesis, Catalysed Reactions and Therapeutic Potential.

Abhishek Tiwari, Varsha Tiwari, Bimal Krishna Banik, Biswa Mohan Sahoo

Medicinal chemistry (Shariqah (United Arab Emirates)) 2023

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Tempol (TP) was introduced in 1960 by Lebedev and Kazarnovskii and is an excellent catalyst extensively used in the synthesis and oxidation of various reagents. 4-Hydroxy-2,2,6,6- tetramethylpiperidin-1-oxyl (TP) has also been explored against various disorders like inflammation, superoxide anion-influenced molecular linked behavioural modifications, radical capturing, cardioprotective, protective ocular damage, against skin burns, fibrocystic diseases, breast cancer prevention, respiratory infections, alopecia, and cerebral malaria, etc. This review article comprises five major aspects of TP namely (a) Approx. 25 different Synthesis schemes of TP (b) major reactions catalysed by TP (c) Therapeutic potential of TP. It also provides scientific information that supports the use of TP which may be proven as a "MIRACLE" drug for the treatment of numerous disorders namely in reducing the reactive oxygen species, superoxide mutases, vision disorders, cancer as well as in covid. It also possesses a significant role in minimising side effects in combination therapy. This review will be beneficial to researchers, healthcare, and academic professionals for further research. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Abhishek Tiwari, Varsha Tiwari, Bimal Krishna Banik, Biswa Mohan Sahoo. Mechanistic Role of Tempol: Synthesis, Catalysed Reactions and Therapeutic Potential. Medicinal chemistry (Shariqah (United Arab Emirates)). 2023;19(9):859-878