Advances in molecular function of p62 protein and its role in diseases].

Xinying Sui, Ping Xu, Changzhu Duan, Yanchang Li

Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2023 Apr 25

filter terms:

Sequestosome 1 (SQSTM1/p62) is a selective autophagy adaptor protein that plays an important role in the clearance of proteins to be degraded as well as in the maintenance of cellular proteostasis. p62 protein has multiple functional domains, which interact with several downstream proteins to precisely regulate multiple signaling pathways, thereby linking p62 to oxidative defense systems, inflammatory responses and nutrient sensing. Studies have shown that mutation or abnormal expression of p62 is closely related to the occurrence and development of various diseases, including neurodegenerative diseases, tumors, infectious diseases, genetic diseases and chronic diseases. This review summarizes the structural features and molecular functions of p62. Moreover, we systematically introduce its multiple functions in protein homeostasis and regulation of signaling pathways. Furthermore, the complexity and versatility of p62 in the occurrence and development of diseases are summarized, with the aim to provide a reference for understanding the function of p62 protein and facilitating related disease research.

Citation

Xinying Sui, Ping Xu, Changzhu Duan, Yanchang Li. Advances in molecular function of p62 protein and its role in diseases]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2023 Apr 25;39(4):1374-1389