Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden.

Kelley Hurst-Hess, Amanda Walz, Yong Yang, Helen McGuirk, Mercedes Gonzalez-Juarrero, Graham F Hatfull, Pallavi Ghosh, Anil K Ojha

Antimicrobial agents and chemotherapy 2023 Jun 15

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Intrinsic and acquired antibiotic resistance in Mycobacterium abscessus presents challenges in infection control, and new therapeutic strategies are needed. Bacteriophage therapy shows promise, but variabilities in M. abscessus phage susceptibility limits its broader utility. We show here that a mycobacteriophage-encoded lysin B (LysB) efficiently and rapidly kills both smooth- and rough-colony morphotype M. abscessus strains and reduces the pulmonary bacterial load in mice. LysB aerosolization presents a plausible treatment for pulmonary M. abscessus infections.

Citation

Kelley Hurst-Hess, Amanda Walz, Yong Yang, Helen McGuirk, Mercedes Gonzalez-Juarrero, Graham F Hatfull, Pallavi Ghosh, Anil K Ojha. Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden. Antimicrobial agents and chemotherapy. 2023 Jun 15;67(6):e0016223