Four new iridoid glycosides from the roots of Rehmannia glutinosa.

Four new iridoid glycosides (1-4), rehmaglutosides L-O, were isolated from the air-dried roots of Rehmannia glutinosa. Their structures were established from the spectroscopic data obtained and by chemical evidence. The known mellittoside (5) and ajugol (6) were also obtained in the current investigation, and the structure of mellittoside was unequivocally defined using X-ray diffraction data. Compounds 1-6 were tested for their cytotoxicity against five human tumor cell lines and proliferation effects on Lactobacillus Reuteri.

Citation

Yan-Fei Liu, Wan-Qi Zhang, Jie Zhou, Guo-Ru Shi, Xin-Yue Li, Ming-Hui Sun, Ruo-Yun Chen, De-Quan Yu. Four new iridoid glycosides from the roots of Rehmannia glutinosa. Journal of Asian natural products research. 2024 Mar;26(3):293-301

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PMID: 37162445

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