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When SLC46A2 delivers cargo into keratinocytes.

Xinxin Wang, Yuping Lai

Immunity 2023 May 09


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  • cytosol (1)
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  • SLC46A2 (2)
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    How pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides from extracellular bacteria to drive keratinocyte inflammation remains unclear. In this issue of Immunity, Bharadwaj et al. show that the solute carrier 46A2 (SLC46A2) delivers DAP-muropeptides into the cytosol to drive NOD1 activation in keratinocytes and elicit skin inflammation during psoriasis. Copyright © 2023 Elsevier Inc. All rights reserved.

    Citation

    Xinxin Wang, Yuping Lai. When SLC46A2 delivers cargo into keratinocytes. Immunity. 2023 May 09;56(5):897-900

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    PMID: 37163988

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