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Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al.1 report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a "sentinel" DC program via the neuropeptide calcitonin gene-related peptide (CGRP), and enhance DC inflammatory responses through direct connections. These neuroimmune units integrate nociceptors' rapid responsiveness with DCs' immune coordination, functioning as an advanced warning system. Copyright © 2023 Elsevier Inc. All rights reserved.
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Theo Crosson, Sebastien Talbot. Decoding nociceptor-DC dialogues. Immunity. 2023 May 09;56(5):906-908
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PMID: 37163991
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