Suitable biomarkers for post-mortem differentiation of cardiac death causes: Quantitative analysis of miR-1, miR-133a and miR-26a in heart tissue and whole blood.

Luise Mildeberger, Julia Bueto, Verena Wilmes, Stefanie Scheiper-Welling, Constanze Niess, Elise Gradhand, Marcel A Verhoff, Silke Kauferstein

Forensic science international. Genetics 2023 Jul

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Cardiovascular diseases are the most common causes of death worldwide. Cardiac death can occur as reaction to myocardial infarction (MI). A diagnostic challenge arises for sudden unexpected death (SUD) cases with structural abnormalities (SA) or without any structural abnormalities (without SA). Therefore, the identification of reliable biomarkers to differentiate cardiac cases from each other is necessary. In the current study, the potential of different microRNAs (miRNAs) as biomarkers in tissue and blood samples of cardiac death cases was analyzed. Blood and tissue samples of 24 MI, 21 SUD and 5 control (C) cases were collected during autopsy. Testing for significance and receiver operating characteristic analysis (ROC) were performed. The results show that miR-1, miR-133a and miR-26a possess a high diagnostic power to discriminate between different cardiac death causes in whole blood and in tissue. Copyright © 2023. Published by Elsevier B.V.

Citation

Luise Mildeberger, Julia Bueto, Verena Wilmes, Stefanie Scheiper-Welling, Constanze Niess, Elise Gradhand, Marcel A Verhoff, Silke Kauferstein. Suitable biomarkers for post-mortem differentiation of cardiac death causes: Quantitative analysis of miR-1, miR-133a and miR-26a in heart tissue and whole blood. Forensic science international. Genetics. 2023 Jul;65:102867