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    In this work, an ultra-sensitive signal quenched photoelectrochemical (PEC) aptasensor for dibutyl phthalate (DBP) detection was constructed by using a target induced cruciform DNA structure as signal amplifier and g-C3N4/SnO2 composite as signal indicator. Impressively, the designed cruciform DNA structure shows high signal amplification efficiency due to the reduced reaction steric hindrance because of its mutually separated and repelled tails, multiple recognition domains, and a fixed direction for the sequential identification of the target. Therefore, the fabricated PEC biosensor demonstrated a low detection limit of 0.3 fM for DBP in a wide linear range of 1 fM to 1 nM. This work offered a novel nucleic acid signal amplification approach for enhancing the sensitivity of PEC sensing platforms for the detection of phthalates (PAEs)-based plasticizer, laying the foundation for its utilization in the determine of real environmental pollutants. Copyright © 2023 Elsevier B.V. All rights reserved.


    Jie Yang, Hongmei Zeng, Yaqin Chai, Ruo Yuan, Hongyan Liu. Ultrasensitive photoelectrochemical biosensor amplified by target induced assembly of cruciform DNA nanostructure for the detection of dibutyl phthalate. Analytica chimica acta. 2023 Jun 29;1262:341242

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    PMID: 37179065

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