Study on the Interaction between Silibinin and Neuraminidase.

Haowen Fang, Yanting Ding, Yi Lu, Bing Niu, Han Lu, Qin Chen

Current pharmaceutical design 2023

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Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity. This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase. In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used. Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase. Silibinin can interact with neuraminidase and inhibit its activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Haowen Fang, Yanting Ding, Yi Lu, Bing Niu, Han Lu, Qin Chen. Study on the Interaction between Silibinin and Neuraminidase. Current pharmaceutical design. 2023;29(16):1266-1273