Correlation Engine 2.0
Clear Search sequence regions

  • astronaut (1)
  • gold (1)
  • hematopoiesis (1)
  • nanoceria (1)
  • oxygen (4)
  • platinum (1)
  • research (1)
  • silica (1)
  • silver (1)
  • species (5)
  • Sizes of these terms reflect their relevance to your search.

    Interest in space exploration has seen substantial growth following recent launch and operation of modern space technologies. In particular, the possibility of travel beyond low earth orbit is seeing sustained support. However, future deep space travel requires addressing health concerns for crews under continuous, longer-term exposure to adverse environmental conditions. Among these challenges, radiation-induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro-gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio-absorption cross-section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon-based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation-induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease. © 2023 Wiley Periodicals LLC.


    Balaashwin Babu, Shreya Pawar, Agastya Mittal, Elayaraja Kolanthai, Craig J Neal, Melanie Coathup, Sudipta Seal. Nanotechnology enabled radioprotectants to reduce space radiation-induced reactive oxidative species. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 2023 Sep-Oct;15(5):e1896

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37190884

    View Full Text