Designed inhibitors to reduce amyloid virulence and cytotoxicity and combat neurodegenerative and infectious diseases.

Rinat Yona Indig, Meytal Landau

Current opinion in chemical biology 2023 Aug

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The review highlights the role of amyloids in various diseases and the challenges associated with targeting human amyloids in therapeutic development. However, due to the better understanding of microbial amyloids' role as virulence factors, there is a growing interest in repurposing and designing anti-amyloid compounds for antivirulence therapy. The identification of amyloid inhibitors has not only significant clinical implications but also provides valuable insights into the structure and function of amyloids. The review showcases small molecules and peptides that specifically target amyloids in both humans and microbes, reducing cytotoxicity and biofilm formation, respectively. The review emphasizes the importance of further research on amyloid structures, mechanisms, and interactions across all life forms to yield new drug targets and improve the design of selective treatments. Overall, the review highlights the potential for amyloid inhibitors in therapeutic development for both human diseases and microbial infections. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Rinat Yona Indig, Meytal Landau. Designed inhibitors to reduce amyloid virulence and cytotoxicity and combat neurodegenerative and infectious diseases. Current opinion in chemical biology. 2023 Aug;75:102318