MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2.

Luxing Peng, Xinjun Huang, Defeng Qing, Heming Lu, Xu Liu, JiaXin Chen, Xianfeng Long, Qiang Pang

Mutation research 2023 Jan-Jun

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This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). Research objects were ascertained using The Cancer Genome Atlas database. Followed by qRT-PCR, western blot, dual-luciferase reporter, MTT, Transwell, and wound healing approaches, we tested gene expression and varying cell behaviors RESULTS: Conspicuously miR-30 family members (miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-30e-5p) downregulation and CBX2 upregulation were discovered in EC cells. miR-30 family members target CBX2 and inhibited CBX2 expression. EC cell behaviors were inhibited by miR-30a-5p/CBX2 axis. MiR-30a-5p draws a new inspiration for EC treatment. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Luxing Peng, Xinjun Huang, Defeng Qing, Heming Lu, Xu Liu, JiaXin Chen, Xianfeng Long, Qiang Pang. MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2. Mutation research. 2023 Jan-Jun;826:111818