Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case.

Li-Ping Zhu, Rui Tang, Qing Wang, Hong Li

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 2023 Jun 30

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Food-dependent, exercise-induced anaphylaxis (FDEIA) is a potentially life-threatening disorder that often occurs with exercise, and patients typically have eaten a specific food within hours before disease onset. This disease is exceedingly rare, with a prevalence of 0.02%. No well-recognized prevention or treatment strategy has been available for FDEIA except avoiding triggers strictly. Here we report an 11-year-old boy with a history of recurrent anaphylaxis of unknown etiology more than 10 times within two years. As the anaphylactic symptoms had not been controlled after traditional treatments, the patient was given subcutaneous injection of dupilumab seven times within 33 weeks. During dupilumab treatments, the patient was exposed to culprit mushrooms plus exercises at least twice a month but without notable anaphylaxis. Thus, Dupilumab may improve the allergic reactions in FDEIA patients.

Citation

Li-Ping Zhu, Rui Tang, Qing Wang, Hong Li. Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 2023 Jun 30;38(2):159-162