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Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus.
Neuron 2023 May 17Sizes of these terms reflect their relevance to your search.
In this issue of Neuron, Sadegh et al.1 identify a novel potential therapeutical target for posthemorrhagic hydrocephalus (PHH). The authors identified that overexpression of Na-K-2Cl cotransporter-1 (NKCC1) in the choroid plexus relieves ventriculomegaly and enhances cerebrospinal fluid (CSF) clearance in improved PHH mouse models. Copyright © 2023 Elsevier Inc. All rights reserved.
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Inyoung Jeong, Nathalie Jurisch-Yaksi. Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus. Neuron. 2023 May 17;111(10):1521-1523
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PMID: 37201502
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