In a recent paper in Science, Chen et al. reported the genetic engineering of S. epidermidis expressing tumor cross-reactive antigens that trigger T cell responses and exhibit anticancer effects after topical administration. Here we discuss direct local effects and indirect systemic effects of exposure to engineered S. epidermidis strains. © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
Oliver Kepp, Laurence Zitvogel, Guido Kroemer. Prevention and treatment of cancers by tumor antigen-expressing Staphylococcus epidermidis. Oncoimmunology. 2023;12(1):2212547
PMID: 37205984
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