Iron metabolism and atherosclerosis.

Qian Guo, Christopher Qian, Zhong-Ming Qian

Trends in endocrinology and metabolism: TEM 2023 Jul

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Despite several decades of study, whether iron is involved in the development of atherosclerosis remains a controversial and unresolved issue. Here, we focus on the up-to-date advances in studies on role of iron in atherosclerosis and discuss possible reasons why patients with hereditary hemochromatosis (HH) do not show any increased incidence of atherosclerosis. In addition, we analyze conflicting results concerning the role of iron in atherogenesis from several epidemiological and animal studies. We argue that atherosclerosis is not observed in HH because iron homeostasis in the arterial wall, the actual location of atherosclerosis, is not significantly affected, and support a causal link between iron in the arterial wall and atherosclerosis. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Qian Guo, Christopher Qian, Zhong-Ming Qian. Iron metabolism and atherosclerosis. Trends in endocrinology and metabolism: TEM. 2023 Jul;34(7):404-413