ILC2s control obesity by regulating energy homeostasis and browning of white fat.

Innate lymphoid cells (ILCs) have been a hot topic in recent research, they are widely distributed in vivo and play an important role in different tissues. The important role of group 2 innate lymphoid cells (ILC2s) in the conversion of white fat into beige fat has attracted widespread attention. Studies have shown that ILC2s regulate adipocyte differentiation and lipid metabolism. This article reviews the types and functions of ILCs, focusing on the relationship between differentiation, development and function of ILC2s, and elaborates on the relationship between peripheral ILC2s and browning of white fat and body energy homeostasis. This has important implications for the future treatment of obesity and related metabolic diseases. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Yuexia Liu, Zunhai Liu, Juntong Liang, Chao Sun. ILC2s control obesity by regulating energy homeostasis and browning of white fat. International immunopharmacology. 2023 Jul;120:110272

Mesh Tags

PMID: 37210911

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