Neurogenomics of Alzheimer's disease (AD): An Asian population review.

Valentinus Besin, Farizky Martriano Humardani, Lisa Thalia Mulyanata

Clinica chimica acta; international journal of clinical chemistry 2023 Jun 01

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Alzheimer's disease (AD) is on the rise worldwide. Generally, AD is considered neurodegenerative when the production and clearance of amyloid-β (Aβ) are imbalanced. Recent research on genome-wide association studies (GWAS) has been explosive; GWAS indicates a relationship between single nucleotide polymorphism (SNP) and AD. GWAS also reveals ethnic differences between Caucasians and Asians. This indicates that pathogenesis between ethnic groups is distinct. According to current scientific knowledge, AD is a disease with a complex pathogenesis that includes impaired neuronal cholesterol regulation, immunity regulation, neurotransmitters regulation, Aβ clearance, Aβ production, and vascular regulation. Here, we demonstrate the pathogenesis of AD in an Asian population and the SNP risk of AD for future AD screening before onset. According to our knowledge, this is the first review of Alzheimer's disease to demonstrate the pathogenesis of AD based on SNP in an Asian population. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Valentinus Besin, Farizky Martriano Humardani, Lisa Thalia Mulyanata. Neurogenomics of Alzheimer's disease (AD): An Asian population review. Clinica chimica acta; international journal of clinical chemistry. 2023 Jun 01;546:117389