Mesotheliomas in Children.

Eduardo Zambrano, Andrés Matoso, Miguel Reyes-Múgica

Advances in anatomic pathology 2023 Jul 01

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Mesotheliomas are rare and aggressive tumors that originate from mesothelial cells. Although exceedingly rare, these tumors may occur in children. Different from adult mesotheliomas, however, environmental exposures particularly to asbestos do not appear to play a major role in mesotheliomas in children, in whom specific genetic rearrangements driving these tumors have been identified in recent years. These molecular alterations may increasingly offer opportunities for targeted therapies in the future, which may provide better outcomes for these highly aggressive malignant neoplasms. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.