Evaporative Crystallization of Simvastatin from Different Solutions Using Mid-Frequency Raman Difference Spectra Explanations.

Xinyuan Chen, Xiuzhi Chen, Hongyan Sun, Xiumin Li, Shizhao Ren, Can Jin, Hongjun Jin, Fenghua Chen, Rongrong Xue

Applied spectroscopy 2023 Jun

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Amorphous simvastatin (amorphous SIM) and Form I of SIM were prepared separately from SIM acetone (AC)/ethyl acetate (ETAC)/ethanol (ET) solutions by simply controlling the solvent evaporation rate, and the kinetic formation of amorphous SIM from SIM AC/ETAC/ET solutions was explained using mid-frequency Raman difference spectra analysis. The mid-frequency Raman difference spectra analysis results indicate that the amorphous phase has close connections with solutions and might be the bridge, playing an important role in the intermediate phase, between solutions and their outcome polymorphs.

Citation

Xinyuan Chen, Xiuzhi Chen, Hongyan Sun, Xiumin Li, Shizhao Ren, Can Jin, Hongjun Jin, Fenghua Chen, Rongrong Xue. Evaporative Crystallization of Simvastatin from Different Solutions Using Mid-Frequency Raman Difference Spectra Explanations. Applied spectroscopy. 2023 Jun;77(6):652-665