A Case of Advanced Esophageal Cancer with Esophago-Bronchial Fistula Closed by Pembrolizumab plus Chemotherapy Therapy].

We report a case of unresectable advanced esophageal cancer with an esophageal fistula that was treated with pembrolizumab plus CDDP plus 5-FU therapy and the fistula was closed. A 73-year-old male was diagnosed with cervical-upper thoracic esophageal cancer and esophago-bronchial fistula on CT and esophagogastroduodenoscopy. He underwent chemotherapy containing pembrolizumab. The fistula was closed after 4 cycles and oral intake became possible. Six months have passed since the first visit and chemotherapy is ongoing. The prognosis of esophago-bronchial fistula is extremely poor, and there is no established treatment, including fistula closure. Chemotherapy containing immune checkpoint inhibitors could considered to be expected not only for local control but also for long-term survival.

Citation

Yoshifumi Kondo, Yoshiro Aoki, Hayato Morita, Shunsuke Morita, Kensuke Shinbara, Naruhiko Honmyo, Takuya Yano, Naoya Nakagawa, Tomohiro Adachi, Mikihiro Kano, Noriaki Tokumoto, Toshihiko Kohashi, Jun Hihara, Hidenori Mukaida. A Case of Advanced Esophageal Cancer with Esophago-Bronchial Fistula Closed by Pembrolizumab plus Chemotherapy Therapy]. Gan to kagaku ryoho. Cancer & chemotherapy. 2023 May;50(5):627-629

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PMID: 37218326

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