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    We here described a method to synthesize α-keto amides from simple sulfoxonium ylides and secondary amines under the catalysis of copper. This transformation involved a very simple and clean catalytic system, and the substrates could be extended to aryl, heteroaryl, and tert-butyl sulfoxonium ylides to give diversified α-keto amides with good yields. Additionally, the mechanistic studies indicated that the α-carbonyl aldehyde might be a key intermediate in the reaction system.


    Xinghua Wang, Yazhou Li, Naixuan Zhao, Hong Liu, Yu Zhou. Copper-Catalyzed Synthesis of α-Keto Amides from Sulfoxonium Ylides. The Journal of organic chemistry. 2023 Jul 07;88(13):8268-8278

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    PMID: 37222407

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